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Gonorrhea is a sexually transmitted disease (STD) caused by the bacterium Neisseria gonorrhea. It tends to infect urethra, vagina, anus, and other sexual organs; even eye or throat area may be affected sometimes. Gonorrhea passes from one person to another due to unprotected sexual practices or persons who have multiple sexual partners.
The World Health Organization (WHO) estimated that the global incidence of gonorrhea increased from 87.7 million in 2005 to 106.1 million in 2008. An article published by Newman et al (2015) estimated the global prevalence of gonorrhea at 0.8% among women aged 15 years to 49 years and 0.6% among men in the same age group in 2012. Rise in new cases of gonorrhea, public awareness about the disease, high rate of diagnosis, high risk of complications, novel therapeutic options, and government regulations about antibiotic uses are the major drivers of the global gonorrhea therapeutics market. However, antibiotic-resistant gonorrhea is a growing concern among physicians.
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A combination vaccine is designed to provide protection against two or more diseases or against single disease caused by completely different or similar organism. A combination vaccine also boosts the immune system to fight against infection. These vaccines contain two or more antigens that are either combined in ready form or mixed before administration. Safety, efficacy, and immunogenicity of a combined immunizing agent are high.
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Pheochromocytoma is an efficient catecholamine-secreting tumor of the adrenal gland medulla. Catecholamines include norepinephrine, epinephrine, and their derivatives. Symptoms of pheochromocytoma include flank skin, elevated heart rate, elevated blood pressure, anxiety, sweating, headache, and weight loss. Within normal limits, norepinephrine and epinephrine hormones are responsible for regulating the blood pressure and heart rate. Excess production of catecholamine due to pheochromocytoma is a reason for high blood pressure with life-threatening and potentially serious difficulties such as stroke and heart attack. Pheochromocytoma occurs most frequently in adults aged between 30 and 60 years. Pheochromocytomas are not life-threatening mostly, but have 10% chances of being cancerous. High blood pressure is the most significant symptom; however, excessive sweating, light-headedness, a fast and pounding pulse when standing, severe headache, rapid breathing, and other symptoms may also occur.